Solid Phase Synthesis and Application of Labeled Peptide Derivatives: Probes of Receptor-Opioid Peptide Interactions
نویسندگان
چکیده
منابع مشابه
Synthesis of nocistatin C-terminal and it’s amide derivatives as an opioid peptide
A new biological active hexapeptide of C-terminal of nocistatin, contains Glu-Gln-Lys-Gln-Leu-Gln sequence was synthesized according to solid phase peptide synthesis on the surface of 2-chloro tritylchloride resin and using fmoc-protected amino acids in the presence of TBTU (O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyl uranium tetrafluoroborate) as a coupling reagent. Then, amidation of the C-te...
متن کاملSynthesis of nocistatin C-terminal and it’s amide derivatives as an opioid peptide
A new biological active hexapeptide of C-terminal of nocistatin, contains Glu-Gln-Lys-Gln-Leu-Gln sequence was synthesized according to solid phase peptide synthesis on the surface of 2-chloro tritylchloride resin and using fmoc-protected amino acids in the presence of TBTU (O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyl uranium tetrafluoroborate) as a coupling reagent. Then, amidation of the C-te...
متن کاملSolid-phase synthesis of peptide-viologen conjugates.
This paper presents a robust method for the conjugation of viologens to peptides using an amide coupling strategy that is compatible with standard Fmoc solid-phase peptide synthesis. Methodology is presented for monitoring the milligram scale process quantitatively by UV spectroscopy. This chemistry enables the synthesis of a broad range of asymmetric viologens in high yield at room temperature...
متن کاملCombinatorial solid phase peptide synthesis and bioassays.
Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and...
متن کاملThe opioid peptide dynorphin A – Biophysical studies of peptide–receptor and peptide–membrane interactions
The opioid peptide dynorphin A Biophysical studies of peptide–receptor and peptide–membrane interactions Johannes Björnerås c Johannes Björnerås, Stockholm 2014 Cover layout by c Malin Augustsson: Artist's impression of a biomembrane system. The following papers, referred to in the text by their Roman numerals, are included in this thesis. PAPER I: Direct detection of neuropeptide dynorphin A b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Peptide Research and Therapeutics
سال: 2008
ISSN: 1573-3149,1573-3904
DOI: 10.1007/s10989-008-9144-1